NRNP 6566 Impact of Pharmacokinetics on Medication Selection and Administration Paper Example

NRNP 6566 Impact of Pharmacokinetics on Medication Selection and Administration AssignmentNRNP 6566 Impact of Pharmacokinetics on Medication Selection and Administration Assignment

NRNP 6566 Impact of Pharmacokinetics on Medication Selection and Administration Assignment Brief

Course: NRNP 6566 – Advanced Care of Adults in Acute Settings I

Assignment Title: NRNP 6566 Impact of Pharmacokinetics on Medication Selection and Administration Assignment

Assignment Instructions Overview

This assignment aims to enhance your understanding of how pharmacokinetics influences medication selection and administration. As an advanced practice nurse (APN), you will be responsible for prescribing medications, and a thorough understanding of pharmacokinetics is essential for effective decision-making. This assignment will explore how knowledge of drug absorption, distribution, metabolism, and elimination can inform your prescribing practices to ensure optimal patient outcomes.

Understanding Assignment Objectives

The primary objective of this assignment is to analyze the impact of pharmacokinetics on medication selection and administration. You will reflect on how pharmacokinetic principles can guide you in adjusting dosages, selecting appropriate drug administration routes, and anticipating potential drug interactions and adverse effects. The goal is to integrate pharmacokinetic knowledge into your clinical practice to improve patient care and safety.

The Student’s Role

As a student, your role is to demonstrate your understanding of pharmacokinetic concepts and their practical application in clinical settings. You will be expected to review the provided learning resources, engage in discussions, and provide specific examples of how pharmacokinetics influences your medication prescribing decisions. Your initial post should be well-researched, clearly articulated, and supported by relevant literature.

Competencies Measured

This assignment will assess your ability to:

  • Apply pharmacokinetic principles to clinical decision-making.
  • Identify factors that affect drug absorption, distribution, metabolism, and elimination.
  • Analyze the implications of pharmacokinetic interactions on medication safety and efficacy.
  • Utilize evidence-based knowledge to optimize medication regimens for diverse patient populations.
  • Communicate your understanding effectively through a structured and well-supported discussion post.

You Can Also Check Other Related Assessments for the NRNP 6566 – Advanced Care of Adults in Acute Settings I Course:

NRNP 6566 Branching Exercise: Cardiac Case 1 Assignment Example

NRNP 6566 Impact of Pharmacokinetics on Medication Selection and Administration Paper Example


As advanced practice nurses (APNs), it is crucial to have a thorough understanding of pharmacokinetics when prescribing medications. Pharmacokinetics involves the study of how a drug is absorbed, distributed, metabolized, and eliminated by the body. This knowledge helps in making informed decisions regarding medication selection and administration, ensuring optimal therapeutic outcomes and minimizing adverse effects.

Importance of Pharmacokinetics in Prescribing Medications

Understanding pharmacokinetics is vital in selecting the appropriate medication and determining the correct dosage and administration route. Factors such as age, gender, and ethnicity can significantly influence pharmacokinetic processes and affect drug efficacy and safety. For instance, elderly patients may have reduced renal function, necessitating dosage adjustments to prevent toxicity (Doogue & Polasek, 2013).

Consider the case of warfarin and amiodarone, where co-administration can increase the levels of both medications. Amiodarone, an antiarrhythmic agent, inhibits the metabolism of warfarin, leading to increased anticoagulant effects and a higher risk of bleeding (Haverkamp et al., 2017). Monitoring and dosage adjustments are essential to manage this interaction safely.

Case Example: Nitroglycerin Administration

Nitroglycerin is a potent vasodilator used primarily for angina pectoris. It is typically administered sublingually rather than orally due to its high first-pass metabolism. When taken orally, nitroglycerin undergoes extensive hepatic metabolism, significantly reducing its bioavailability and effectiveness (Willenbring et al., 2018). Sublingual administration bypasses the liver, allowing rapid absorption and onset of action, which is crucial during angina attacks.

The sublingual route is preferred because the thin sublingual epithelium allows for quicker absorption into the systemic circulation compared to the thicker buccal mucosa (Akhter et al., 2022). This method ensures that sufficient drug levels are achieved promptly, providing rapid relief from angina symptoms.

Other Medications with Non-Oral Administration Routes

Some medications are not suitable for oral administration due to poor absorption or significant first-pass metabolism. For example, vaginally administered medications like progestogens, estrogens, and antifungals are used to treat conditions such as yeast infections. The vaginal route provides a local effect and avoids the first-pass metabolism, ensuring higher drug concentrations at the site of action (Leyva-Gómez et al., 2019).


In summary, understanding pharmacokinetics is crucial for APNs in prescribing and administering medications. It allows for personalized treatment plans that consider individual patient factors, ensuring effective and safe therapeutic outcomes. By being aware of how drugs are absorbed, distributed, metabolized, and eliminated, APNs can make informed decisions that optimize patient care.


Akhter, A. S., Gumina, R., & Nimjee, S. (2022). Sublingual Nitroglycerin Administration to Relieve Radial Artery Vasospasm and Retrieve Wedged Catheter: A Consideration in Neuroangiography. Stroke: Vascular and Interventional Neurology.

Doogue, M. P., & Polasek, T. M. (2013). The ABCD of clinical pharmacokinetics. Therapeutic Advances in Drug Safety, 4(1), 5-7.

Haverkamp, W., Breithardt, G., Camm, A. J., Janse, M. J., Rosen, M. R., Antzelevitch, C., … & Hoffman, B. F. (2017). The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology. European Heart Journal, 21(15), 1216-1231.

Leyva-Gómez, G., Del Prado-Audelo, M. L., Ortega-Peña, S., Mendoza-Muñoz, N., Urbán-Morlán, Z., González-Torres, M., … & Cortés, H. (2019). Modifications in Vaginal Microbiota and Their Influence on Drug Release: Challenges and Opportunities. Pharmaceutics, 11(5), 217.

Willenbring, B. A., Schnitker, C. K., & Stellpflug, S. J. (2018). Oral Nitroglycerin Solution May Be Effective for Esophageal Food Impaction. The Journal of Emergency Medicine, 54(5), 678-680.

Detailed Assessment Instructions for the NRNP 6566 Impact of Pharmacokinetics on Medication Selection and Administration Assignment

Discussion: Pharmacokinetics and Pharmacodynamics

Impact of Pharmacokinetics on Medication Selection and Administration

As an advanced practice nurse, you will likely be responsible for selecting and prescribing pharmaceuticals to address your patients’ health needs and concerns. To what extent is understanding the pharmacokinetics of a certain medication important in your decision-making process when prescribing a medication for your patient?

Knowing the pharmacokinetic effects of medications—such as how long will the medication be absorbed and exert an effect on the body before it is eliminated—can have important implications for addressing your patient’s health needs.

Photo Credit: Getty Images/Ingram Publishing

For this Discussion, think about the types of decisions you might make, with an understanding of pharmacokinetics, when prescribing medications for your patients. Reflect on how having a working knowledge of pharmacokinetics of medications is important in your role as an advanced practice nurse.

To Prepare

  • Review the Learning Resources on pharmacokinetics.
  • Review the Discussion Prompt and Response Prompt assigned by your Instructor.

By Day 3 of Week 1

Post your response to the Discussion Prompt assigned by your Instructor. Be specific and provide examples.

Note: For this Discussion, you are required to complete your initial post before you will be able to view and respond to your colleagues’ postings. Begin by clicking on the “Post to Discussion Question” link and then select “Create Thread” to complete your initial post. Remember, once you click on Submit, you cannot delete or edit your own posts, and you cannot post anonymously. Please check your post carefully before clicking on Submit!

Learning Resources

Required Readings (click to expand/reduce)

Doogue, M. P., & Polasek, T. M. (2013). The ABCD of clinical pharmacokinetics. Therapeutic Advances in Drug Safety, 4(1), 5–7. doi:10.1177/2042098612469335

Sakai, J. B. (2008). Practical pharmacology for the pharmacy technician. Philadelphia, PA: Jones & Bartlett Learning. • Chapter 3, “Pharmacokinetics: The Absorption, Distribution, and Excretion of Drugs” (pp. 27–40).

Required Media (click to expand/reduce)

Speed Pharmacology. (2015, April 7). Pharmacology – pharmacokinetics (made easy) [Video file]. Retrieved from

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